August 9, 2019 posted by

The use of Macrol Tablet may change kidney blood urea nitrogen and blood creatinine. Therefore blood glucose levels should be monitored during concomitant administration of clarithromycin and disopyramide. In more severe infections, the dosage can be increased to 2 tabs daily. More details about our sourcing methodology. Increased serum levels have been reported Bi-directional drug interactions Atazanavir Both clarithromycin and atazanavir are substrates and inhibitors of CYP3A, and there is evidence of a bi-directional drug interaction. If this is possible, discontinue the macrolide.

Your doctor will explain this to you. Caution is advised when verapamil and other calcium channel blockers such as verapamil, amlodipine , diltiazem are given in combination with Macrol. When Macrol is given in combination with tolterodine, 1 mg of tolterodine twice a day is recommended in patients who are deficient in CYP2D6 activity. Before you use Macrol Tablet , tell your doctor of your medical history including yellowish discoloration of the skin, liver dysfunction, group of disorders that affect nervous system acute porphyria , abnormally low levels of potassium , abnormally low levels of magnesium , decreased heartbeat, or abnormal heartbeats QT prolongation, ventricular arrhythmia of the heart, including torsades de pointes. In order to avoid this you should leave a 4 hour interval between taking these medicines. The dispensing label will tell you how much of this medicine you should take and how often you should take it.

The use of Macrol Tablet may change liver enzymes tablef such as alanine transaminase, aspartate transaminase, gamma-glutamyltransferase, GGT alkaline phosphatase, lactate dehydrogenase, and total bilirubin.

Etravirine Clarithromycin exposure was decreased by etravirine; however, concentrations of the active metabolite, OH-clarithromycin, were increased. Furthermore, it marcol be necessary to monitor the plasma levels of the CYP3A inducer, which could be increased owing to the inhibition of CYP3A by clarithromycin see also the relevant product information for the CYP3A4 inhibitor administered. This medicinal product does not require any special temperature storage conditions.

Table 3 is a suggested guide for determining Dosage: Clarithromycin is used to treat: Macrol extended-release tablets works best if it is taken at the same time each day. Consideration should be given to official guidance on the appropriate use of antibacterial agents. For Helicobacter Pylori Infections: Long-term use may, as with other antibiotics, result in colonization with increased numbers of non-susceptible bacteria and fungi.


HMG-CoA Reductase Inhibitors statins Concomitant use of clarithromycin with lovastatin or simvastatin is contraindicated hablet section 4. Elderly patients Infection with Mycobacterium avium Ongoing ototoxic treatment Severe hepatic failure Severe renal failure Lactation Pregnancy. Reports of alterations of the sense of smell including smell loss, usually in conjunction with taste perversion or taste loss, have also been reported.

Filmm have been reports of interstitial nephritis coincident with Macrol use. Specifically, Macrol is 6-O-methyl marcol A. When clarithromycin mg is given three times daily, the clarithromycin plasma concentrations are increased with respect to the mg twice daily dosage.

When treated with antibacterial agents the normal flora of the colon gets altered, leading to overgrowth of C. Macrol usage may increase the risk of abnormal heart rhythm and irregular heartbeat. Patients taking oral contraceptives should be warned that if diarrhoea, vomiting or breakthrough bleeding occur there is a possibility of contraceptive failure.

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Use of Clarithromycin tablets is not recommended for children younger than 12 years. Clarithromycin is contraindicated in patients with known hypersensitivity to macrolides antibiotic drugs or to any of its excipients as listed in section 6. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. When midazolam was co-administered with clarithromycin tablets mg twice dailymidazolam AUC was increased 2. Uncommon may effect up to 1 in people: Xospata Xospata gilteritinib is a kinase inhibitor indicated for the treatment of patients who have relapsed or Traveling With Medication Ensure that you carry enough doses of each of your prescription medicines to last the entire trip.

Pancreatitis acute, tongue discolouration, tooth discoloration.

Course of Action Regular macrll, biological and electrocardiographic monitoring. When clarithromycin and digoxin are administered together, inhibition of Pgp by clarithromycin may lead to increased exposure to digoxin.

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To decrease the possibility of side-effects, you might be recommended to use the extended-release form of this medicine by your doctor. There have been post-marketed reports of Torsades de pointes occurring with concurrent use of Macrol and quinidine or disopyramide.

The following severe side-effects may also occur when using Macrol Tablet:. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Macrol. If you forget to take this medicine Take it as soon as you remember. Clinical studies using various different H. Hypersensitivity Macrol is contraindicated in patients with a known hypersensitivity to Macrol, erythromycin, or any of the macrolide antibacterial drugs.


Transient CNS events including anxiety, behavioral changes, confusional states, convulsions, depersonalization, disorientation, hallucinations, insomnia, depression, manic behavior, nightmares, psychosis, tinnitus, tremor, and vertigo have been reported during post-marketing surveillance. This may result in sub-therapeutic levels of clarithromycin leading to reduced efficacy.

For some infections, you may be instructed to take two mg tablets or one mg tablet twice a day.

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The organisms include Haemophilus influenzae; Streptococcus pneumoniae; Streptococcus pyogenes; Streptococcus agalactiae; Moraxella Branhamella catarrhalis; Neisseria gonorrhoeae; H. Other possible side effects Tell your doctor if any of the following side effects bother you. Therefore, caution should be exercised in administering the antibiotic to patients with impaired hepatic function.

Qualitative m quantitative composition 3. Elevated digoxin serum concentrations have been reported in patients receiving Macrol tablets and digoxin concomitantly. The usual duration of treatment is for days depending on the pathogen involved and the severity of the condition. Concomitant administration of Macrol and oral anticoagulants may potentiate the effects of oral anticoagulants.

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The following medicines may weaken the effect of Clarithromycin: Separately, remove tableg personal information including the prescription label from the medicine packaging and then dispose off the container. In this population subset, inhibition of CYP3A results in significantly higher serum concentrations of tolterodine. Please follow your doctor’s instructions carefully. Significant increase in concentrations of ticagrelor due to the reduced hepatic metabolism, with decreased concentrations of its active metabolite.

The consumption ,g alcohol with Macrol can worsen the sleepiness.