CYTOTOXIC AGENTS OF THE CRINANE SERIES OF AMARYLLIDACEAE ALKALOIDS
Chemical constituents of Crinum asiaticum L. De Leo 2 Estimated H-index: The plants of Narcissus pallidulus Ganymedes section show a predominance of Sceletium-type compounds, which are quite rare in the Amaryllidaceae family Amongst the most challenging issues, the Moffatt transposition and the orthoamide problem, which required a blocking manoeuvre to regiospecifically distinguish the C, hydroxyl group for rearrangement were considered to be the severe cases. Ivo Doskocil 5 Estimated H-index: Site tools A-Z Lists. Chemistry, biology, and medicinal potential of narciclasine and its congeners. The aim of this work was to investigate the alkaloid patterns of Lapiedra martinezii and their relation to biogeography and phenology focused in a phylogenetic comparison.
Flower bulb production creates large amounts of leftover biomass. Alkaloids from Habranthus tubispathus and H. Biogeographical patterns and phenological changes in Lapiedra martinezii LAG.
Cytotoxic agents of the crinane series of amaryllidaceae alkaloids.
In this study, the Amaryllidqceae African Amaryllid Boophone haemanthoides was examined chtotoxic its phytochemical composition and cytotoxicity. Access the full text: The selectivity towards different cancer cell lines of the synthesized derivatives is discussed Given these interesting biological properties and their natural abundance, plants of the Amaryllidaceae have provided a diverse and accessible platform for phytochemical-based drug discovery.
Acetyl- and butyrylcholinesterase inhibition was observed for the extracts lakaloids from bulbs of H The maximal contents of galanthamine and lycorine Study on pharmacokinetic and tissue distribution of lycorine in mice plasma and tissues by liquid chromatography-mass spectrometry. Pancratistatin occurs naturally in Hawaiian spider lily, a flowering plant within the Amaryllidaceae family. Traditional usage, phytochemistry and pharmacology of the South African medicinal plant Boophone disticha L.
Diastereoselective intramolecular nitroaldol entry to lycoricidine alkaloids. In this study, we demonstrated that haemanthamine, haemanthidine and serie showed strong cytotoxicity against pmutated Caco-2 and HT colorectal adenocarcinoma cells as quantified in terms of IC50 values.
Plants of the Amaryllidaceae family are known to synthesize alkaloids, which have shown Aeries inhibitory activity. From This Paper Figures, tables, and topics from this paper.
Apoptosis-inducing effects are demonstrated for distichamine in human acute lymphoblastic leukemia CEM cells.
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After removal of the silyl function, a cyclic sulfate was installed to obtain product Nair 5 Estimated H-index: Alzheimer’s disease AD is a neurodegenerative disorder associated with memory impairment and cognitive deficit.
Amongst the most challenging issues, the Moffatt transposition and the orthoamide problem, which required a blocking manoeuvre to alkaloivs distinguish the C, hydroxyl group for rearrangement were considered to be the severe cases. The crinnae precursor 3 with its stereocenters in the C ring is stereoselectively synthesized from the cis -disubstituted cyclohexene 4. Pancratistatin is thought to have potential as a basis for the development of new pharmaceuticals,  particularly in the field of cancer treatment.
Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. Full deprotection agentss 38 by BBr 3 and methanol afforded pancratistatin 3 in 12 steps from commercially available pinitol with an overall yield of 2. Tomas Hudlicky 43 Estimated H-index: Kittisak LikhitwitayawuidCindy K.
Chromatographic separation was performed on an Amethyst C18 column 4. Deposit and Record Details.
Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells
Synthetic herbicides are mainly used, although they cause a range of problems, and integrated weed control through application of naturally occurring allelochemicals would be highly desirable.
Sand Daffodil Pancratium maritimum is a world-wide endangered Amayllidaceae species and represents an important anti-cancer medicinal resource due to alkaloids production. Alkaloids from Boophone haemanthoides Amaryllidaceae. Biological samples were processed with ethyl acetate by liquid-liquid extraction, and evodiamine was used as the internal standard.
The free hydroxyl of this was subsequently substituted by an azide to give Showing of 3 citations. Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile. Read also provides personalized recommendations to agebts you up to date in your field. KhanaJohn P. In addition, the substance absorption and metabolism of F. The plants of Narcissus pallidulus Ganymedes section show a predominance of Sceletium-type compounds, which are quite rare in the Amaryllidaceae family AlexEapen P.
Most of the drugs currently available for the treatment of AD are acetylcholinesterase AChE inhibitors. Dengue is a systemic viral infection that is transmitted to humans by Aedes mosquitoes.
Several methanol and chloroform extracts were observed to inhibit germination and growth of Senecio vulgaris L